Hence, the DSP is one major bottleneck for the commercialization of biological products. Although several conventional DSP technologies have been widely employed, they are usually expensive and time-consuming and often provide only low recovery yields. Stripping is usually carried out in either a packed or trayed column.Nowadays, there is an increasing demand to establish new feasible, efficient downstream processing (DSP) techniques in biotechnology and related fields. In industrial applications the liquid and vapor streams can have co-current or countercurrent flows. The stripping process is a physical separation process where one or more components are removed from a liquid stream by a vapor stream.
Column (pulse, stirred, rotating contactors).Type of liquid-liquid extraction process can be performed by means following methods: Neutralizing acids and bases (as acrylates, nitrated organics and chloro-benzene compounds).Food industry applications (flavors, fragrances).Recovery reaction products caprolactam and adiponitrile from nylon production.Agricultural chemical extraction (herbicides and pesticides).Essential oil extraction (bio-oil is produced from: biomass pyrolysis).Protein separation and purifications (recovering of antibiotics, amino acid, steroids from fermentation broth).Removal of carboxylic acid (acetic, formic acid, succinic acid, valeric acid from fermentation yeast, pelargonic acid from bio oil processing).Removal of high boiling organics from wastewater (Phenol, amine, aromatics) that cannot treat by conventional and common process treatment.Fermentation and algae broths (carboxylic acid, acetic acid, algae oil extraction).(LLE) has several industrial applications: Further purification, such as distillation, crystallization or second extraction might be needed. If the aim of the process is to achieve a pure extract, the LLE as a downstream process is most often only the initial step. Thus, right selection of the solvent in achieving a sustainable process is required and it creates challenges to the large-scale industry implementation of the process. (LLE) require a large consumption of possibly toxic solvent, which also when recycled in the system requires costly equipment. If the distillation process is not feasible and convenient, because the component (solute) to be recovered is heat sensitive, non-volatile, high boiling point or azeotrope mixture cannot allow the purification.After a chemical reaction as part of the work-up, often including an acidic work-up.The solvent that is enriched in solute(s) is called extract the feed solution that is depleted in solute(s) is called the raffinate. There is a net transfer of one or more species from one liquid into another liquid phase, generally from aqueous to organic. In this separation process, second liquid solvent is added which is immiscible or partially miscible with the feed and the solutes of the mixture are distributed between the two phases based on their relative solubilities. Engineering & Contracting (PSC) is expert in Liquid-liquid extraction (LLE) also known as solvent extraction and partitioning: a method to separate constituents (solutes) of homogeneous liquid solutions.
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